Third Space Syndrome

S s of hypovolemia hypotension tachycardia low central venous pressure decreased urine output.

Third space syndrome. What oncologic emergency occurs secondary to extensive surgical procedures immunotherapy or septic shock. Albumin is a predominant protein within the intravascular space that increases colloidal oncotic pressure. Third space syndrome third space fluid compartments in the mammalian body broadly comprise two compartments each with several subdivisions. Third spacing occurs with low albumin levels secondary to the reduced ability of the intravascular space to keep fluid within or pull fluid back from the interstitial space.

With regard to severe burns fluids may pool on the burn site i e. What are the manifestations of third space syndrome. Loss of extracellular fluid from the vascular to other body compartments. A popular verb for haemorrhage or other accumulation of fluids into the so called 3rd space or physiologic compartment the interstitial space between the skin and fascia that isn t normally perfused with fluids.

Third spacing occurs when fluid moves from the intravascular compartment where it does contribute to cardiac output into a body compartment where it cannot contribute to cardiac output. Third space syndrome involves a shifting of fluid from the vascular space to the interstitial space that primarily occurs secondary to extensive surgical procedures biologic therapy or septic. Farlex partner medical dictionary farlex 2012. Third spacing third spacing is the abnormal accumulation of fluid into an extracellular and extravascular space.

It can be seen in a variety of disease processes including liver failure and chf. Third spacing is the physiological concept that body fluids may collect in a third body compartment that isn t normally perfused with fluids. Third space fluid shift is the mobilization of body fluid to a non contributory space rendering it unavailable to the circulatory system. In medicine the term is often used with regard to loss of fluid into interstitial spaces such as with burns or edema but it can also refer to fluid shifts into a body cavity transcellular space such as ascites and pleural effusions.

This can cause potentially serious problems such as edema reduced cardiac output and hypotension. Here s a quick break down of the three different kinds of fluid spacing. Fluid lying outside of the interstitial tissue exposed to evaporation. Ascites is definitely a type of third spacing.