Mitochondrial Intermembrane Space

Mitochondria contain two aqueous compartments.

Mitochondrial intermembrane space. In living cells cytochrome c is confined to the mitochondrial intermembrane space where it participates as an electron carrier in the respiratory chain in apoptotic cells cytochrome c leaves its normal mitochondrial localization and accumulates in the cytoplasm where it binds to the adaptor molecule apaf 1. Mitochondria contain two aqueous compartments. The mitochondrial intermembrane space ims houses a large spectrum of proteins with distinct and critical functions. Protein import into this mitochondrial sub compartment is underpinned by an intriguing variety of pathways many of which are still poorly understood.

Ella bossy wetzel douglas r. The mitochondrial intermembrane space ims harbors a diverse set of proteins that fulfill important tasks e g in mitochondrial protein import detoxification of reactive oxygen species and. The intermembrane space is the region between the inner membrane and the outer membrane of a mitochondrion or a chloroplast. Since both mitochondrial membranes are only a few nanometers apart the ims is a rather tiny compartment of the cell.

Whereas many of the biologic functions of the matrix were well characterized in the past it became clear very recently that the intermembrane space plays a pivotal role in the coordination of mitochondrial activities with other cellular processes. It is also known as perimitochondrial space. The matrix and the intermembrane space. The mitochondrial intermembrane space is the space between the outer membrane and the inner membrane.

Simplified structure of a mitochondrion the intermembrane space ims is the space occurring between or involving two or more membranes. Channel protein s called porins in the outer membrane allow free movement of ions and small molecule s into the intermembrane space. Its main function is nucleotide phosphorylation. E embedded in the inner mitochondrial membrane.

The matrix and the intermembrane space. Green in methods in enzymology 2000. The intermembrane space ims of mitochondria is enclosed by the outer and the inner membrane of the organelle. Whereas many of the biologic functions of the matrix were well characterized in the past it became clear very recently that the intermembrane space plays a pivotal role in the coordination of mitochondrial activities with other cellular processes.

C embedded in the outer mitochondrial membrane. Because the outer membrane is freely permeable to small molecules the concentrations of small molecules such as ions and sugars in the intermembrane space is the same as in the cytosol. B located in the intermembrane space of mitochondria. A embedded in both mitochondrial membranes.